The B vitamins and parasites (disease)

[Kritters]

With so much I have read regarding diseases and parasites, vitamin B has popped up so repeatedly that I have no doubt there is an intimate connection and one that can make a difference in prevention, treatments and cure of many diseases.

Although, as 2manyfibers has shown, all vitamins are crucial in this respect, for some reason the B's are directly imlicated with parasites. They have yet to make the connection, but it's there. With 2many's keen and diligent research skills, maybe he will put it together.

Here is some preliminary info I've collected with the intention of accumulating more to see what shakes. If nothing else, the B's will give you more energy and help with the CFS.
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INOSITOL VIT B 8

Inositol
Panic disorders, ocd, etc.

Goats: goat, internal parasites, b vitamins

Also, any stressful situation will send a message to the body for any of the internal parasites to develop in huge numbers- so a good deworming is in order. (stress such as moving, kidding, disbudding, castrating and animal attacks all can bring on a worm situation) I use Ivomec

Vitamin and cofactor biosynthesis pathways in Plasmodium and other apicomplexan parasites

Résumé / Abstract
Vitamins are essential components of the human diet. By contrast, the malaria parasite Plasmodium falciparum and related apicomplexan parasites synthesize certain vitamins de novo, either completely or in parts. The various biosynthesis pathways are specific to different apicomplexan parasites and emphasize the distinct requirements of these parasites for nutrients and growth factors. The absence of vitamin biosynthesis in humans implies that inhibition of the parasite pathways might be a way to interfere specifically with parasite development. However, the roles of biosynthesis and uptake of vitamins in the regulation of vitamin homeostasis in parasites needs to be established first. In this article, the procurement of vitamins B1, B5 and B6 by Plasmodium and other apicomplexan parasites is discussed.


Brazilian Journal of Medical and Biological Research - Vitamin B1 and B6 in the malaria parasite: requisite or dispensable?
Talks about synthesis by parasites de vono

As P. falciparum, the most dangerous human malaria parasite, is rapidly developing resistances against most of the currently available drugs, there is an urgent need to identify new targets in Plasmodium metabolism that can be specifically inhibited without affecting the human host. One of these might be vitamin biosynthesis. Vitamins
Research - EU Research strategy to infectious diseases - VITBIOMAL


Summary:
Plasmodium falciparum causes severe malaria and about 2 million human deaths annually. The main obstacle to combat the disease is increasing resistance of the parasites to existing drugs and the lack of a protective vaccine. Therefore, it is imperative that new suitable drug targets in the parasite`s metabolism are identified, assessed and validated. The availability of the parasite`s genome sequence offers an excellent tool to identify metabolic pathways potentially essential for parasite survival. Scrutinising the Plasmodium genomes revealed that they possess biosynthetic pathways for vitamins. Vitamins are organic compounds required in small amounts to ensure normal metabolic functions. Since they are not synthesised by humans, they need to be supplied via nutrients in trace amounts. The absence of vitamin biosynthesis in humans suggests that specific targeting of these parasite pathways with inhibitors is feasible. Thus, vitamin biosynthesis of Plasmodium might offer excellent potential for the development of novel chemotherapeutics against malaria with specific toxicity towards the parasites without affecting the host’s metabolism. In the first instance, we will focus on vitamin B6 biosynthesis, as this important nutrient is required as a co-factor for a wide variety of essential metabolic functions in protein and amino acid metabolism, and has also has been implicated in the defence against oxidative stress in other eukaryotes. Using reverse genetic approaches, we will validate the suitability of two of the vitamin B6 synthesising enzymes Pdx1 and Pdx2 respectively as drug targets. In addition, their precise biological functions and potential interactions with other cellular components will be analysed. Further, the biochemical, biophysical and structural features of both enzymes will be assessed in order to be able to rationally design specific inhibitors that interfere with the parasite’s proteins activities and functions.


Background:

belonging to the vitamin B complex such as thiamine (B1), riboflavin (B2), pyridoxine (B6) and cobalamin (B12) cannot be synthesised by mammals and have to be taken up in their diet. In contrast, micro-organisms, including the malarial parasites, fungi and plants, possess de novo biosynthetic pathways that provide these organisms with an intrinsic source of these essential compounds. Of all the water-soluble vitamins that are present in blood plasma, the only one for which the intracellular parasite apparently has an absolute requirement and for which the parasitised cell must consequently have the appropriate uptake system, is B5, the precursor of coenzyme A. Therefore, there is a hypothesis that the parasites most likely possess biosynthetic pathways for the other water-soluble vitamins. This hypothesis is supported by the presence of genes in the parasite genome that encode proteins and enzymes necessary for the biosynthesis of a number of vitamins, including those for lipoic acid synthesis, the vitamin and coenzyme precursor chorismate and vitamin B6 biosynthesis.


DerKeiler informative website

B Complex B Complex Vitamins effects of lack of vitamin by’s

Botany online: Interactions - Plants - Fungi - Parasitic and Symbiotic Relations - Mycorrhiza

Many fungi are heterotrophic regarding vitamins, and are therefore dependent on a supply by the plant. The required spectrum of nutrients differs nevertheless from species to species. Many mycorrhizal fungi can be isolated and cultivated, but they do hardly ever develop fruiting bodies under such conditions.
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B Vitamins & Ruminants by Karin Christensen from the July/August, 2007 issue of Dairy Goat Journal. Presenting information, ideas, and insights for everyone who raises, manages, or just loves goats.


Large, single-cell rumen protozoa have a requirement for many B vitamins and do not make their own. They probably get most of what they require when they eat bacteria, which they enjoy in large numbers, but may use up some of those vitamins free in rumen fluid. This could account for some of the ruminal loss of supplemented vitamins. It is known that in normal conditions rumen protozoa use biotin that is available in the diet and seem to have some negative effect on bacterial use or synthesis of biotin under certain conditions.

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MORE TO FOLLOW
KRITTS

[Jo]

Thanks Kritts,

Great info!

I take 125mg of Inositol a day and now wonder if I should take more. My pills say that there is no RDA for it and some of those studies used up to 12g!

Interesting that lots of parasites have bio-synthesize pathways for B vits, and we dont. Wonder how that plays out inside us.

Also clocked that bit about cayenne pepper being a wonderful blood stop - stopping bleeding almost instantly! Useful info maybe for the lesion busters amongst us.

I'll look forward to the next installment!!

Jo xxx

[Kritters]

LOL love that comic! I have a B-complex AND a personality complex. LOL

yes, I thought about that this morning. think I'll pick a scab and try it out LOL

I think the information available is not only mixed, but nothing is being put together. They say parasites on the one hand can make their own, but the large one-celled protozoa can't as we can't. hmmm. wonder what the difference is and which ones can and can't.

I also think we have a deficiency because the critters we have are making their own from our resources (nasty, selfish little devils) One article I read mentions the importance of us taking more because they are using up our stores, but then I'm wondering if the more we take, the more they have to multiply and develop, you know?

Someone has to figure out how to prevent them from catabolizing our sources to metabolize their own OR how to make our sources unusable for them to take.

This is supposedly the reason we have ocd, suicidal thoughts, depression, mental fatigue, ADD, panic disorders and CFS.

Time to up my intake and get with it!!!

xxoo
Kritts

[Baraka Obam]

I read a book written by a doctor that was FIRST a Veterinarian, he said when treating animals the usual outcome was vitamins and minerals, while people received no such thing, only drugs! He also said the food given to people was lacking in nutriants because of soil depleation. Instead of just grinding up the correct rocks for minerals they produce a chemical that will mimic but would improve the looks of the plant not the value of nutritian to the body, This is a wonderful book with doctors terms so you can understand their lingo. Even though he was a doctor he saw early on that the profession had taken a turn for the worse. The books name, (DEAD DOCTORS DON"T LIE) refers to the fact that many of them die earlier than their counterparts in other professions, it is not saying all doctors lie.

[Kritters]

Hey Barak,

Really? Doctors die more than other professions? wow. I do know that dentists have a high rate of death caused by cancer. gee, do you think it would have anything to do with x-ray exposure, bacteri.a exposure, the fact that they know no one wants to see them, etc? hey but the money's good so enjoy life while you're a good young dentist.

So, now here we are. what fun. not only do we have franken diseases, but our food is no longer nutritional because of bio-engineering, radiation and pasturization, not to mention the critter and toxic chemical infested soil it is forced to attempt to grow in, and now they are going to illegalize our attempts to fortify ourselves with vitamins, not to mention the vaccines which are introducing us to all kinds of fun stuff.

Ain't life just so grand?

Kritts

[Baraka Obam]

Well look at the good side of this, we are not being born, blind today with another disease inside us growing waiting to destroy us before we are 20. As for the food do not forget that the meat we eat is also fed with unnatural stuff such as steroids, antibiotics and water retention drugs. Why sell meat when you can sell $100 bucket of water ! I wonder if any of these drugs we eat in the meat will bother HUMANS, Naaaaaaaaaa, Hey why don't we give the cattle our last line of defence antibiotic, you know the one we use when we can't stop a disease any other way, GREAT IDEA!!! Why dont we package all the food in plastic and add chemicals to the foods, I want some of that for sure, I want to be the first on my block to watch my children bite into a big plastic additive icecream bar from China. You know China is being faulted for adding things to food, WE taught them this nasty habit they just havent got the mixture right. In AMERICA we do NOT kill our people in one meal as often as China our food will do it in 30 years, if that ain't cutting edge tecnology I do not know what is!!!!!!!!!!!!!!!!!!

[Kritters]

I'm lovin ya Obam

[Natalie]

Mom, I mean Kritts, I took my vitamin Bs today! And i found an old bottle( two years old ) of Paragone. It has Black walnut hull, pau d arco, garlic, quassia, wormwood, clove, rosemary, pumpkin and grapefruit. Other good stuff too!

Im such a child. I get pissed off and want nothing to do with getting tough. I want to eat cheese cake and drink champagne. Dumb huh?

Im getting better. And I read all of your info on both of your awesome posts! I had to reread to understand Albert Einstein but Im getting there!!

Love you!!

[Kritters]

good girl, Nat! I won't give you 'time out' even if you need one tomorrow ...

I gotta tell ya...I had been having panic attacks and scared, sick feelings, a lot lately. In just the short time I found this information about vit B's I began to take more b12 and b6 and haven't had any major attacks. small, teensy, uh-oh here it comes feeling, but then....nope. I don't know how the b's accomplish this, and don't know how much people need or how long it takes to actually settle in to do the work, or any of the particulars, but B's are water soluable vitamins, so you'll pee out what your body doesn't need..just like vitamin C. I wouldn't go overboard, but no one REALLY knows how much of the B's and C's one can take. Linus Pauing is a hero IMO. I wish he were still alive. He is known for his vit C mega theory, but in actuality he was an amazing scientist known for work in DNA and more as well. If I'll listen to anyone, it would be him.

Champagne and cheesecake sound AWESOME! GO FOR IT! (but not too much or I WILL give you a time out, young lady :-)

love you back,
Kritts