Cutaneous Larva Migrans

[Kritters]

Cutaneous Larva Migrans

Has this been brought to the forum's attention before?

I'm wondering how medical professionals could ever dismiss what are similar to some symptoms of Morgs when there is actually this derm disease very well documented and is caused by hookworm & transmitted through cats and dogs. Crawling and burrowing through skin.

Just amazing.

Kritts

[Kritters]

Hey, check this one out:

Cutaneous Sarcoidosis: A Dermatologic Masquerader - April 15, 2002 - American Family Physician

Cutaneous Sarcoidosis: A Dermatologic Masquerader


".............The underlying cause of sarcoidosis remains unknown.1 Although the disease can occur at any age, in persons of either gender, and in all races, older studies suggest that sarcoidosis more frequently affects persons who are of Scandinavian, Irish, or black descent............."

THE UNDERLYING CAUSE REMAINS UNKNOWN....hmmmm, seems I've heard that said before. Oh, I know, I know! google any disease they know nothing about which is caused by a parasitic micro-organism (fungi, bacterium, nematodes, viruses...) which they also know nothing about.

Blah, blah, blah.

Don't know what causes it and there is no cure. Hmm. could they all be the SAME ORGANISM IN DIFFERENT FORMS CALLED BY DIFFERENT NAMES?

Kritts

[niecy]

Kritts, I already tried to make a post, and it logged me out! awwrrrr.......

The very first thing the new doctor that I went to last week thought of was......Sarcoidasis........she did blood work, plus a few other body fluids to see if I have it. LOL I should find out on Monday what the results are.

Here's my first response to your new thread.......good thing I copied it.

Niecy
xoxoxo



Hey Kritts, I just couldn't resist commenting on your post. I was up all night last night searching all the different diagnoses that we have had, and how they could be connected to HOOKWORM!!!

This is the first file I made, and there are lots more.

I got an email this week talking about how America's beaches are severely infected with E-Coli.

This is just a little more info on hookworms, I will post more later.

Hope you are all doing well.

Niecy


Blackwell Synergy - Immunol Rev, Volume 171 Issue 1 Page 163-171, October 1999 (Article Abstract)


Acknowledgements
This research was supported by grants AI32726 and AI39461 from the National Institutes of Health, an Established Investigator Grant from the American Heart Association, a Clinical Research Grant from the March of Dimes, and a Parasitology Grant from the China Medical Board of New York, Inc.
Abstract

Summary: Hookworm infection is a major parasitic cause of morbidity in the developing nations of the tropics. Development of a genetically engineered vaccine would be a useful tool in the control of this infection in highly endemic areas. Recombinant polypeptides belonging to the Ancylostoma secreted protein (ASP)-1 family have shown promise for reducing hookworm burdens after larval challenge infections in mice. Typically, these polypeptides are expressed in Escherichia coli and administered as an alum precipitate. Vaccine protection is antibody dependent. It is anticipated that a cocktail of different recombinant hookworm antigens may be required in order to effectively prevent heavy hookworm infections and disease. The progress of this work has been hampered by the absence of both a convenient laboratory animal with which to study hookworm infections resembling human infection, as well as the lack of easy availability of native hookworm antigens. In addition, useful human serologic correlates of antihookworm immunity are still poorly defined.



As I said there is ALOT more info on hookworms, in America in particular, I will try to get together a file on all the information I have. This is most definitley the major cause for CLM in America.

I was told in the very beginning of my illness(by a veterinarian) that it looked like I had a worm, and he specified hookworm, traveling in my skin. Any worm that tunnels is considered CLM.

The bio-chemist that I met said he is almost 100% sure I have a major hookworm infection, and my property is most likely heavily infested also. He is the one who mentioned the reason it hasn't been diagnosed is the identity markers of the organism and my body are identical. And it is also possible that this may be an as yet unidentified species of hookworm.

Jo posted on that topic, I think it was MIH, Microphage something......sorry Jo, I would have to search the archives.

My next step is to search far and wide to see if there is a possibility that hookworms can get infected with agrobacterium, it doesn't sound completely rediculous considering that humans are accidental hosts of hookworm, and we contact it from the dirt (and by the way, one of the MOST common places to contract hookworm is on beaches, as people walk thier animals, dogs in particular on our public beaches)........and agrobacterium also lives in the soil.

Just my two-cents today.
Niecy
xoxoxo

[Kritters]

Niecy!
Excellent! I'm sure Jo will fill us in. Funny how there is info on the forum from earlier posts but until we have the eureka moment ourselves related to our own research, we don't really notice.

I think your two cents is not far fetched. I was thinking myself about how these organisms and bio-altered agro-bacterium or some other virus (such as in the herpes family) could 'hook' up (no pun intended) hey wait! I think I remember Jo saying something similar to the hook up thing... but not sure (she and I always say similar stuff) so that may be in her post.

Anywho, I'm investigating the herpes involvement and I gotta tell ya, what I'm learning ain't pretty.

xoxoxoxo
Kritts

[Kritters]

by the way, Niecy...welcome back sweetiepie!
xoxo
Kritts

[tcmgpt13]

Here is a post by Jo which mentions the Cutaneous Larva Migrans and which has a different reference (second link in post):

Worm Removed From Woman's Brain

And yes, good to see you here and posting again Niecy.

tcmxxx

[Jo]

Hello peeps,

Great to see ya Niecy ;o)

I just thought I'd mention some things about things.

I first looked into Cutaneous Larva Migrans (CLM) a while back - it seemed the only logical reason for my itchy skin, which was irritating not just me but others around me.

CLM is caused by many nematodes, when they are larvae stage and infiltrate the skin. I looked at research by the Liverpool School of Tropical Medicine - which are leading the field in filarial type infections (just got $30 million from Bill Gates to research malaria).
http://www.liv.ac.uk/lstm/research/index.htm

Micro filariae can be identified through biopsy of skin samples, or peripheral blood (eg nicked from a finger) and examined via a scope on a slide.

According to Stricker et al, filariae have not been found in skin biopsies from morgellons patients. (maybe they should look at the peripheral blood under a scope? I cant imagine that Lacey and I are the only ones that test positive for microfilariae??)

Some docs just do a blood test and if the results come back with a high eosinophilia, then a nematode infection might be suspected…..ummmm, BUT, eosinophils don’t always present…….why??

As far as I can fathom, the anti-viral (TH1) and anti-parasitic (TH2) pathway levels can affect each other - when TH1's high, TH2 can be suppressed and vice versa.

Re-activated herpes will stimulate the anti-viral pathway (TH1). This will cause suppression of the anti-parasitic pathway - suppressing both IgE and eosinophil counts.

BUT some nematodes can put out chemicals to increase TH1 as a survival mechanism too!!! (little clever ***tards)

This maybe one reason why nematode infections are not suspected - especially knowing that Morgs often have high tilters for HH6 and VZV

I've heard of sufferers having hook worm, whip worm, Strongyloids Stercoralis - Harvey has said he's found Onchocerca and Dracunculus insignis. And more recently Cryptostrongylus Pulmoni….

They can be co-infections, sometimes found in patients with altered immunity - especially Lyme, CFS and the like. And hence why all Morgs should de-worm every 6 months at least, in my opinion.

However, if Morgellons is proved to utilise a DNA store to replicate or mimic a variety of organisms, why not a nematode too??

And about nematodes carrying bacteria - its useful to remember Andy Coyles research about the nematode Heterorhabditis bacteriophora carrying the pathogen Photorhabdus asymbiotica. I've tried contacting Andy about progress on his research, but no luck yet ....anyone else know the score???
The G.M.O SCANDAL THAT IS ABOUT TO ENGULF THE WORLD!! - by Andy Coyle

TH1/TH2 refs:
http://www.immunesupport.com/chronic-fatigue-syndrome-causes.htm
http://members.aol.com/SynergyHN/roundworm

[jonsi]

Jo wrote "However, if Morgellons is proved to utilize a DNA store to replicate or mimic a variety of organisms, why not a nematode too??"

Before I knew anything about "Morgellons" I felt something tickling my upper lip, like tiny hairs were falling out of my nose, Well, the only way to investigate the area was to...(you get the picture). After getting some "specimens" and looking at the shape (they were all similar in shape) I pulled out my biology book and found a picture of a nematode. I found my match. However, the pictures in the book said they were microscopic, my nematodes are very visible (varying, avg. 1/4 inch long.

Itwl,
~jonsi

[niecy]

Hey Kritts & all!!!

I told you I was up all night the other night. This is just one more of several things I found about hookworms, and other parasites.

My problem with this whole ordeal is that our powers that be want to pretend that these diseases don't occur in the United States........it is hard to find as much information for the US, but it is there, I have just got to dig a little more.

I wonder about this organism that they have found that causes toxemia in pregnant women, resulting in many deaths of the mother, and the unborn child. This disease of pregnancy has been around for literally decades........they are just now finding the organism.......they still "don't" know what it is. It is just a "micro-organism", I'm with you Kritts, I wonder if all of these unidentified organisms are closely related.

Hugs and prayers!!
Niecy
xoxoxo


http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1360348

Hookworms are blood-feeding nematodes that infect 740 million people in developing countries (4). Antihelminthics are the current method of control, but increasing drug resistance in nematodes of livestock and rapid reinfection following treatment of infected people have facilitated the need for recombinant vaccines (14, 17).

Most hookworms infect a host by penetrating the skin, although some species are orally infective. Third-stage infective larvae (L3) of the dog hookworm, Ancylostoma caninum, and the major human hookworm, Necator americanus, are developmentally arrested and wait in the soil or on blades of grass to come into contact with a mammalian host. They attach to the host upon skin contact and penetrate via hair follicles, eventually entering blood or lymphatic capillaries. Feeding recommences upon exposure to serum components (, and the worms resume development. They are passively carried to the pulmonary microcirculation, where they undergo tracheal migration by penetrating into the alveoli, to be swept in mucus up the airways and then down into the gut.


http://iai.asm.org/cgi/content/full/74/9/4970

Infection and Immunity, September 2006, p. 4970-4981, Vol. 74, No. 9
0019-9567/06/$08.00+0 doi:10.1128/IAI.07-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Innate Immune Responses to Lung-Stage Helminth Infection Induce Alternatively Activated Alveolar Macrophages{dagger}
Joshua J. Reece, Mark C. Siracusa, and Alan L. Scott*


W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland
Received 28 April 2006/ Returned for modification 21 June 2006/ Accepted 29 June 2006


http://health.nytimes.com/health/guides/disease/hookworm/news-and-features.html
New York Times
Saturday, May 31, 2008
Health Guide
Attack Of The Worms
July 2, 2007 - By NICHOLAS D. KRISTOF - Editorial Desk - 738 Words

AIDS is the disease in the global spotlight. But it’s also time to devote more money to other ailments.
Gateses Give $47 Million to Bolster Coordinated Assaults on Diseases
December 20, 2006 - By CELIA W. DUGGER - Foreign Desk - 424 Words

The Bill & Melinda Gates Foundation is giving $47 million in grants for the control of neglected tropical diseases, now almost forgotten in wealthy nations, that still cause excruciating pain, disfigurement and disability for millions of the world's poorest people, the recipients announced yesterday. The grants are unusual in that they do not single out individual diseases. Instead, they aim to test the idea that diseases such as trachoma, river blindness, lymphatic filariasis and hookworm, which largely afflict the rural poor, can be tackled together more effectively and cheaply than one at a time.


Beyond Swollen Limbs, a Disease's Hidden Agony
April 9, 2006 - By DONALD G. McNEIL Jr. - Foreign Desk - 2235 Words

Health experts hope to eliminate lymphatic filariasis, which causes lymph nodes to swell, within a generation.
Ideas & Trends
In the Shadow of AIDS, a World of Other Problems
June 24, 2001 - By STEPHANIE FLANDERS - Week in Review Desk - 1430 Words


SEVENTEEN million Africans dead and 25 million infected with H.I.V. have made their point. At this week's Special Session of the United Nations General Assembly, ministers and experts will agree that a multibillion dollar war on AIDS is global priority No. 1. They will say that, and they will mean it. But when talking about aid for the poorest countries, things are seldom that simple. ''AIDS is a catastrophe,'' said Dr. Lant Pritchett, a former economist at the World Bank who teaches development economics at Harvard. ''And it's not fair, if treatments exist, not to give them to all these people who are dying. But it's also not fair that more than a third of children in Africa are malnourished. It's not fair that maybe 140 babies in every 1,000 will die before the age of 1, and more than a third will never learn to read. All of it is unfair. Unfairness is not the test for action.''
For most of Western history, the average child walked around with a bellyful of parasitic worms: pinworms, tapeworms, hookworms. Then modern civilization came along, put shoes on the children's feet, installed sewers and stopped using human waste as fertilizer, and the worms mostly disappeared. But there may be a downside to all this hygiene. Children in industrialized countries, which are relatively worm-free, have a much greater tendency than those in other countries to grow into adults with autoimmune disorders (in which the body is attacked by its own immune system), like rheumatoid arthritis, multiple sclerosis, lupus and inflammatory bowel disease.
Panel Says Deadly Illness Can Be Eradicated
September 22, 1992 - Science Desk - 398 Words

A pork tape worm illness that causes about 50,000 deaths worldwide every year could be eradicated someday, an international task force has concluded. About 50 million cases of the pork tape worm disease, or taeniasis-cysticercosis, were reported worldwide last year. It is most prevalent in less developed countries like those in Latin America, Africa and Asia, where pigs often run loose in villages, said Dr. Peter Schantz of the Federal Centers for Disease Control in Atlanta.
Parasites Take the Biological Spotlight
July 17, 1990 - By NATALIE ANGIER - Science Desk - 2575 Words


LEAD: TO the ancient Greeks, the word ''parasite'' meant one who eats at the table of another. But far from having the decency to sit down for dinner, most parasites in nature suck the blood, sip at the gastric juices of the intestines, pierce into the nourishing warmth of muscle tissue and otherwise leech rudely off the fluids and labors of their unwilling hosts.
Foundation Backing Project To Fight Parasitic Illnesses
October 18, 1984 - UPI - National Desk - 83 Words


A $20 million research campaign against parasitic illnesses that plague about three billion people worldwide is being started by the John D. and Catherine L. MacArthur Foundation. Malaria, amoebic dysentery, hookworm and African sleeping sickness are the key targets of the research in the United States, Mexico, Australia and Israel. ''Diseases caused by parasites afflict more than half the world's people,'' said Dr. Jonas Salk, chairman of the MacArthur Board Health Committee.
MICRO-ORGANISM IS SUSPECTED AS MAJOR KILLER IN PREGNANCY
January 27, 1983 - UPI - National Desk - 449 Words

Researchers today reported the discovery of a micro-organism they believe is linked to toxemia of pregnancy, which may cause the deaths of up to five million expectant mothers and fetuses worldwide each year. Toxemia of pregnancy is the second most important cause of maternal and fetal death, after hemorrhage, according to health officials. ''About 5 to 10 percent of all pregnant women will have the disease,'' Dr. Silvio Aladjem, chairman of Loyola University Medical Center's obstetrics and gynecology department, said in an interview. He said the incidence of the disease worldwide was hardly, if at all, affected by prevailing conditions of sanitation and general health.

[niecy]

Jo, I didn't know if you knew anything about this journal, it is peer reviewed, and it has links where you can ask for other undiagnosed diseases to be considered for an article.

Kritts, I see the words: hookworm, herpes, and candida in this article........all in one article. Hmmmm.....

Niecy
xxxxxx


PLoS Neglected Tropical Diseases: A Peer-Reviewed Open-Access Journal

PLoS Neglected Tropical Diseases Journal Scope

PLoS Neglected Tropical Diseases is an open access journal devoted to the pathology, epidemiology, prevention, treatment and control of the neglected tropical diseases (NTDs), as well as public policy relevant to this group of diseases. The NTDs are defined as a group of poverty-promoting chronic infectious diseases, which primarily occur in rural areas and poor urban areas of low-income and middle-income countries. They are poverty-promoting because of their impact on child health and development, pregnancy, and worker productivity, as well as their stigmatizing features.

The major NTDs that are within the scope of PLoS Neglected Tropical Diseases are listed below:
Protozoan Infections

* Amebiasis
* Balantidiasis
* Chagas Disease
* Giardiasis
* Human African Trypanosomiasis
* Leishmaniasis

Helminth Infections

* Taeniasis-Cysticercosis
* Dracunculiasis
* Echinococcosis
* Food-borne Trematodiases
* Loiasis
* Lymphatic Filariasis
* Onchocerciasis
* Schistosomiasis
* Soil-transmitted Helminthiases (Ascariasis, Hookworm Diseases, Trichuriasis, Strongyloidiasis)
* Toxocariasis and other Larva Migrans

Viral Infections

* Dengue
* Japanese encephalitis
* Jungle yellow fever
* Other arboviral infections
* Rabies
* Rift Valley fever
* Viral hemorrhagic fevers

Bacterial Infections

* Bartonella
* Bovine Tuberculosis in Humans
* Buruli Ulcer
* Cholera
* Enteric pathogens (Shigella, Salmonella, E. coli)
* Leprosy
* Leptospirosis
* Relapsing Fever
* Trachoma
* Treponematoses (Bejel, Pinta, Syphilis, Yaws)

Fungal Infections

* Mycetoma
* Paracoccidiomycosis

Ectoparasitic Infections

* Scabies
* Myiasis

Areas of Emphasis

All aspects of these diseases will be considered, including their pathogenesis, clinical features, pharmacology and treatment, diagnosis, epidemiology, vector biology, and vaccinology and prevention. Demographic, ecological and social determinants, public health, and policy aspects of these diseases (including cost-effectiveness analyses) will also be a priority. PLoS Neglected Tropical Diseases is pleased to publish relevant in vitro and animal studies as well as human investigations.

The journal is organized to provide additional support for authors from endemic countries and such authors are particularly encouraged to submit their research to PLoS Neglected Tropical Diseases.
Nutritional Diseases (Is it possible that America may be becoming an endemic country? Ascariasis is endemic on the gulf coast in the United States.)

Papers that examine the link between nutrition and NTD infection will be considered for PLoS Neglected Tropical Diseases.
HIV/AIDS, Malaria, and Tuberculosis

The "big three" diseases, HIV/AIDS, malaria, and tuberculosis, will not generally be considered for PLoS Neglected Tropical Diseases. Authors of papers on these three diseases should continue to submit them to one of the seven other PLoS journals as appropriate. An important exception is when these three diseases are considered in the context of co-infections with the NTDs. For example, PLoS Neglected Tropical Diseases is interested in papers that explore integrated control of the NTDs and the "big three"diseases. Another exception is that PLoS Neglected Tropical Diseases will consider papers on all aspects of bovine tuberculosis affecting humans.
Fundamental Microbial Pathogenesis

It is recommended that papers on fundamental microbial pathogenesis and the molecular and cellular biology of the NTDs pathogens should be considered for PLoS Pathogens. Examples of papers that might be more appropriate for PLoS Pathogens would be papers on fundamental mechanisms of immune evasion by Plasmodium, blocking of apoptosis by Salmonella, population biology of Candida, or latency in herpes viruses. In contrast, papers examining molecular pathways as potential drug or vaccine targets would be more suitable for PLoS Neglected Tropical Diseases. As described above, other papers more suitable to PLoS Neglected Tropical Diseases are papers on health product (i.e., drug, diagnostic, and vaccine) development, human immunology, clinical manifestations, surveillance and epidemiologic research, public health control, and health policy aspects of the NTDs.
Other Infections

Other infectious diseases will also be considered on a case-by-case basis through a presubmission inquiry to the editors. Authors should indicate in their pre-submission inquiry why they consider the infection to be a neglected tropical disease.
Public Policy

In addition to scientific and medical investigative articles, PLoS Neglected Tropical Diseases is committed to all aspects of the NTDs that are relevant to global public health, including important public policy statements.

Accordingly, PLoS Neglected Tropical Diseases will have an engaging magazine section with dedicated editors. The magazine section will contain opinion pieces, debates, policy papers, expert contaries on research articles, reviews, problem-based educational articles (from the laboratory, clinic, and field), interviews, and historical profiles and perspectives.