Member Mold Treatment Suggestions-2

[tcmgpt13]

This was posted by Carla for Pat who has been a wonderful source of useful information. Has one suggestion for a prescription anti-fungal:

Originally Posted by carla

This is posted on Pat's orders

Fungal News

http://www.mesothelioma-asbestosis.info/valley-fever-coccidioidomycosis-news/european-union-approves-noxafil-posaconazole-for-fungal-infections-coccidioidomycosis-treatment
During the clinical trials, NOXAFIL has reportedly demonstrated broad-spectrum activity covering both Yeasts and Moulds that are known to cause various (which could be life threatening especially for those who are immunocompromised or immunosuppressed*) invasive fungal infections.
Now that European Union has authorized Schering- Plough Research Institute to market NOXAFIL in EU, the company will be able to offer this unique anti-fungal oral suspension in not only the current 25 EU member states, but also in Iceland and Norway.
NOXAFIL is often prescribed for invasive diseases such as Aspergillosis, Coccidioidomycosis, Chromoblastomycosis, Fusariosis, and Mycetoma in adult patients with refractory disease, or for the adult patients that do not respond to the common antifungal agents.
The triazole agent was found to be effective for the treatment of fungal infections caused by Fusarium (responsible for chromoblastomycosis and mycetoma) and Coccidioides. It must be noted, however, that Posaconazole should not be used in conjunction with ergot alkaloids, CYP 3A4, and HMG-CoA reductase inhibitors.


Aspergillosis is caused by a fungus (Aspergillus), which is commonly found growing on dead leaves, stored grain, compost piles, or in other decaying vegetation.
http://www.doctorfungus.org/mycoses/human/human_index.htm
It causes illness in three ways: as an allergic reaction in people with asthma (Pulmonary aspergillosis - allergic bronchopulmonary type); as a colonization and growth in an old healed lung cavity from previous disease (such as tuberculosis or lung abscess) where it produces a fungus ball called aspergilloma; and as an invasive infection with pneumonia that is spread to other parts of the body by the bloodstream (Pulmonary aspergillosis - invasive type).
The invasive infection can affect the eye, causing blindness, and any other organ of the body, but especially the heart, lungs, brain, and kidneys. The third form occurs almost exclusively in people who are immunosuppressed because of cancer, AIDS, leukemia, organ transplants, high doses of corticosteroid drugs, chemotherapy, or other diseases that reduce the number of normal white blood cells.
Histopathologic Features of the Most Commonly Encountered Fungi

Achieving a successful histopathologic diagnosis begins with selection of the tissue sample to be examined. While some fungi are more readily located at the periphery of the infected lesion, others are more prominent at the center. Then comes the use of appropriate stains and examination by experienced eyes. The major growth forms of the fungi that help in histopathologic diagnosis are the yeast cells, hyphae, pseudohyphae, arthroconidia, chlamydoconidia, and spherules. The characteristics of each of these (shape, size, location, color...) help in identification of the fungus. Tissue components such as Russell bodies, karyorrhectic debris, calcified bodies, elastic fibers, and small blood vessels may resemble fungi. Careful examination by experienced specialists significantly reduces such an overdiagnosis.

Paul again this time discussing Phaeohyphomycosis and oregano oil:

Phaeohyphomycosis

Originally Posted by 10meters

Rinsho Byori, 1999 Oct, 47(10), 976 - 9
{Subcutaneous phaeohyphomycosis of the right thumb}; Maekura S et al.; Black fungi are a group of fungi that are characterized by the development of a pale brown to black color in the cell walls of their vegetative cells, conidia, or both . A mycotic infection caused by a member of black fungi can be subdivided into three clinical entities: phaeohyphomycosis, chromoblastomycosis, and mycetoma . Phaeohyphomycosis is distinguished from mycetoma by the absence of grain (organized, interwoven mycelial aggregates) formation, and from chromoblastomycosis by the absence of sclerotic bodies (thick-walled muriform cells) . Phaeohyphomycosis is a rare disease and has been sporadically reported . In the present report, phaeohyphomycosis of the right thumb of a 72-year-old man was presented . A precipitating trauma of two months earlier at the site was recalled . A solitary mass, 10 mm in diameter, was gradually formed in the palm side of the distal right thumb and finally resected . Histological examination disclosed a solitary granulomatous lesion surrounded by an incomplete fibrous capsule . The lesion mainly involved subcutaneous tissue and was composed of multiple pyogranulomas . Pigmented branched septate hyphae and yeast-like cells were sparsely found in the periphery of the abscess and within histiocytic cells of the granulomas . No sclerotic cells were detected . When pigmentation of black fungi in tissue is as faint as in the present case, Fontana-Masson staining is useful to accentuate the presence of melanin-like pigment of fungal cell walls.

Oregano essential oil in inhibiting fungus

Lett Appl Microbiol, 1999 Oct, 29(4), 238 - 41
Inhibitory effects of some spice essential oils on Aspergillus ochraceus NRRL 3174 growth and ochratoxin A production; Basilico MZ et al.; Inhibitory effects of essential oils of oregano (Origanum vulgare), mint (Menta arvensis), basil (Ocimum basilicum), sage (Salvia officinalis) and coriander (Coriandrum sativum), on the mycelial growth and ochratoxin A production by Aspergillus ochraceus NRRL 3174 were studied . Cultures were incubated on yeast extract-sucrose (YES) broth, at concentrations of 0, 500, 750 and 1000 p.p.m . of essential oils during 7, 14 and 21 d at 25 degrees C . At 1000 p.p.m., oregano and mint completely inhibited the fungal growth and ochratoxin A production up to 21 d, while basil was only effective up to 7 d . At 750 p.p.m., oregano was completely effective up to 14 d, whereas mint allowed fungal growth but no ocratoxin A production up to 14 d . At 500 p.p.m., no evident inhibition could be in observed with any of the essential oils under analysis . Sage and coriander showed no important effect at any of the concentrations studied . These inhibitory effects are interesting in connection with the prevention of mycotoxin contamination in many foods and they could be used instead of synthetic antifungal products.