Bacterial Translocation

[fritolay66]

For the past couple of months, I have been looking into this avenue. I believe the information that follows has applications in the biotoxin illnesses and the Morgellons arena. Remember, biotoxin illness includes environmental toxins as well as infectious disease in which produce toxins. This also means Lyme Disease.

I have been trying for sometime to go back and put togeher the information I have gleaned over the last couple of months. My time is limited, and so there for, when I normally do not cut and paste exclusively, today in order to get this information out there, thats exactly what I am going to do for now to introduce it to you.

Fair Use Excerpt

"In recent years it has been increasingly recognized that the gastrointestinal tract has functions other than simply the digestion and excretion of foodstuffs. The gut is also a metabolic and immunological organ that serves as a barrier against living organisms and antigens within its lumen. This role is termed ‘gut barrier function’. The fact that luminal contents in the caecum have a bacterial concentration of the order of 1012 organisms per millilitre of faeces,1 whilst portal blood and mesenteric lymph nodes are usually sterile, dramatically illustrates the efficacy of this barrier function.

The idea that the alimentary tract, teeming with its own bacterial flora, could represent a source of sepsis under certain conditions has interested clinicians for many years. This theory, usually referred to as the ‘gut origin of sepsis’ hypothesis, is not new. In the late nineteenth century, the idea developed that peritonitis could result from the passage of bacteria from organs adjacent to the peritoneal cavity. In Germany this was referred to as durchwanderungs-peritonitis, literally translated as ‘wandering through peritonitis’. In 1891 and 1895, two separate investigators hypothesized that viable bacteria could pass through the intact gut wall in vivo.2,,3 These findings were confirmed after the Second World War by Fine and colleagues4 who were able to detect viable bacteria in the peritoneal cavity of dogs in a haemorrhagic shock model. Schatten et al.5 demonstrated that bacteria could migrate from the gastrointestinal tract into the portal circulation in the absence of an infective process in humans. Subsequently it has become clear that, in addition to Gram-negative bacteria, endotoxin, Gram-positive bacteria and fungi can pass through the mucosal barrier.6 In 1979, Berg and Garlington7 defined this phenomenon as ‘bacterial translocation’.

The term ‘bacterial translocation’ is used to describe the passage of viable resident bacteria from the gastrointestinal tract to normally sterile tissues such as the mesenteric lymph nodes and other internal organs.7 The term also applies to the passage of inert particles and other macromolecules, such as lipopolysaccharide endotoxin, across the intestinal mucosal barrier. "

Current status of bacterial translocation as a cause of surgical sepsis ? Br Med Bull

Microbiology of bacterial translocation in humans -- O?Boyle et al. 42 (1): 29 -- Gut

BioMed Central | Full text | Microscopy of bacterial translocation during small bowel obstruction and ischemia in vivo - a new animal model

Some sources state that this can happen spontaneously. I believe something triggers it and from the work I have done, I don't believe this to be a normal process.

The information concerning Bacterial Translocation has direct applications such as in burn cases, intestinal blockage cases, acute pancreatitis cases, cirrhosis cases, and is also associated with certain applications of pharma drugs including some types of antibiotics, as well as concerns in probiotic administration and its sometime ill associated side affects.

Two people came to my mind as I have been studying this. Andy Coyle and Karen. And then of course us as a group. I do believe some of us suffer from active unidentified infections, but then there are those of us whom test consistently do not. (If ones MSH were low, one becomes susceptable to normal indigenous bacteria that wouldn't test out as abnormal from a lab)

In biotoxin illness, when MSH is low, mucous membranes are most definately affected. That would include the lumen of the intestinal tract. In the case of pancreatitis, overproduction of mucous within the GI tract occurs as a protective measure of the body, and then backs up into the pancreatic duct of the pancreas from the intestine. One would then have mucous shoved into the pancreas and the longer allowed to occur, the more problems to occur within the pancreas. Same thing with intestinal obstruction.

Frito

Read more: LymeBusters - Bacterial Translocation

[janedoe]

umm, in eglish? maybe im kinda stupid, but parts of that caught my attention.. could you repost in language for dummys like me? thanks/.

[fritolay66]

Could you tell me which parts make sense so I have some place to start?

Frito

Edited to add...

I wrote a long post explaining the background of biotoxin illness and during that time, about twenty minutes, my login logged me off and my post went to cyberspace.

I have to work, and Jane, I did try to respond. Will write more later tonight after I get home. They really should do something about this site automatically logging people off after a certain period of time especially when they are in the post window.

[tcmgpt13]

Hey there Frito,

Good to see ya!

I just wanted to make sure you know to check the little remember box next to your name when you sign in (if you don't already). That should help keep you signed in for a longer period of time. Usually, too, if you don't check that box a drop down notification will show you that you are no longer signed in when you try to put on your post. Simply bring up an additional window, sign in again on MDR with that window, and then you will not lose your post on the other window, as you are once again signed in. As a just in case scenerio be sure to copy your post so you can paste it in case it does disappear despite all prior preparations.

I enjoyed your post here. I, too, believe the gut is a crucial and overlooked key to this illness. I suffered from an intestinal blockage this last winter. Thank goodness for the TCM herbs which cleared this up for me (the doctors were only making me sicker). I believe this blockage was caused by some worms in the small intestine as it was when my TCM guy added the formula for the small intestine that these parasites showed up in my stool. This illness is definitely no picnic. Why this happened when it did who knows? I just feel fortunate to have had the help I did. I often wonder if Andy Coyle had a similar issue. I cannot help wondering why these intestinal issues seems to be happening to so many people with Morgellons. This conundrum hopefully will be understood someday.

I don't know if anyone has posted this information from Venetia over at LB, if not you will be interested in this:

AMA confirms Morgellons Systemic- origin in gut

I find this extremely important information which so far does not seem to have been looked into any further. We can only hope it will be as more and more reports of bowel symptoms are reported by Morgellons patients. Anna R. Key just reported a prolonged hospital stay with bacterial infections she said tested from her own body. This seems to be along the lines of what you are discussing in your post here:

CDC's Scientific report on Morgellons is done

Hope you are doing okay these days.

tcm

[janedoe]

wow, the site has a huge page on PERMISIONS,'just because you say fair use doesnt mean you dont have to ask permission

[Baraka Obam]

I HAVE ALSO HAD THESE SORT OF ISSUES IN THE COLON, FROM MILD TO WILD, ALL KINDS OF STUFF.

When i had a gallblader there was other problems included severe problems.

I wish they would have given me the thing back in a jar, I WANT MY MAYPO, NO I WANT MY GALLBLADDER.

There was one small gift I did receive from the operation, that was a stone, I have that stone, I will bet there are some fibers coming out of it.

I have also noticed when I take probiotics that I get kidney irritation, can it be that the bacteria that is created in the lab has an affect on other organs. ya gotta wonder.

Very interesting post, its good to see posts change to a more intelligent venue.

[Katinka]

Originally Posted by fritolay66

I have to work, and Jane, I did try to respond. Will write more later tonight after I get home. They really should do something about this site automatically logging people off after a certain period of time especially when they are in the post window.

Hi Frito, very interesting subject! I'll come back and add my other posts if you wish here too.

Just wanted to tell you..if you check the 'remember me' right next to the login it won't happen that you get automatically logged out after a while....happened to me many times and I know it's very aggravating esp. after writing a long post.

Keep up the good work!
Kat


oops..just now saw tcm solved the log out problem already..sorry tcm...it's early, haven't had enough coffee yet....

[fritolay66]

Hi TC!! Its really good to see you too!! Thanks for the heads up with the checkmark in the box, but my screen doesn't have it. ??

Doing very well and hope you are too.

Hi B, how was the beach? hehe.

I remember you telling me about your kidneys and probiotics, and so far, I found a little something. In bacterial translocation, not only do the indigenous bacteria and such have the ability to cross the intestinal barrier, but also all the toxins and macromolecules such as undigested proteins also have that ability. This results in antigens and an immune reaction. This is also what contributes to autoimmunity issues many develop. And it is due directly to the antigens in reaction to what has crossed the intestinal barrier. With an overload of toxins in the body and then also translocating across the intestinal barrier, the kidneys would have to take some kind of hit. And the kidneys are also associated with the immune system as being a part of it. I suspect the reaction you experienced while taking probiotics, and having bacterial translocation occuring, would then somewhat briefly explain why you experienced what you did.

Hi Tink!!

Absolutely add your other posts! Thanks for the heads up on the remember me by the login, but my login doesn't have that. I will look again.

Nice to see you too.

Frito

[Jo]

Thanks for the info Frito!

We've got 7 metres of tubing to keep well...that's one heck of a job. Is the lumen basically wet skin? If this white debris and fibres are leached from skin, is a similar thing happening internally? I mean, does lumen have pores for instance (for things to lurk and breath through?)

We can leach the same crap from our mouths, as from our skin, so it stands to reason the rest is at risk of the same.

lol sorry for the ponderings!!

Hope you are keeping ok

Jo xx

[fritolay66]

We've got 7 metres of tubing to keep well...that's one heck of a job. Is the lumen basically wet skin? If this white debris and fibres are leached from skin, is a similar thing happening internally? I mean, does lumen have pores for instance (for things to lurk and breath through?)

The lumen of the intestine should not be pourous to the bacteria that reside in it, candida can literally punch holes through it, and when the food we eat becomes particles in which are then presented to the immune system, the body develops inappropriate immune responses. Obviously it is porous to the nutrients and enzymes to be taken up and delivered to the body. But when you have a disfunction in your intestinal system and a disfunction in your immune system, then this process can be very damaging.

Frito