Mast cell disruption?

[Jo]

Hi there,

I've just been reading up about mast cells. I've never really heard people talk about them, but reading this - its ringing some bells I feel. Maybe Morgies have a mast cell disruption???

Jo xxx

"A mast cell (or mastocyte) is a resident cell of several types of tissues and contains many granules rich in histamine and heparin. Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing and defense against pathogens

Mast cells are present in most tissues in the vicinity of blood vessels, and are especially prominent near the boundaries between the outside world and the internal milieu, such as the skin, mucosa of the lungs and digestive tract, as well as in the mouth, conjunctiva and nose.


Mast cells play a key role in the inflammatory process. Allergens are generally proteins or polysaccharides. It appears that binding of two or more IgE molecules (this is called crosslinking) is required to activate the mast cell. Although this reaction is most well understood in terms of allergy, it appears to have evolved as a defense system against intestinal worm infestations (tapeworms, etc).


Several lines of evidence suggest that mast cells may have a fairly fundamental role in innate immunity -- they are capable of elaborating a vast array of important cytokines and other inflammatory mediators, they express multiple "pattern recognition receptors" thought to be involved in recognizing broad classes of pathogens, and mice without mast cells seem to be much more susceptible to a variety of infections.


Many forms of cutaneous and mucosal allergy are mediated for a large part by mast cells; they play a central role in asthma, eczema, itch (from various causes) and allergic rhinitis and allergic conjunctivitis."

Mast cells are implicated in the pathology associated with the autoimmune disorders rheumatoid arthritis, bullous pemphigoid, and multiple sclerosis. They have been shown to be involved in the recruitment of inflammatory cells to the joints (e.g. rheumatoid arthritis) and skin (e.g. bullous pemphigoid) and this activity is dependent on antibodies and complement components.[citation needed]

Mastocytosis is a rare condition featuring proliferation of mast cells. It exists in a cutaneous and systemic form, with the former being limited to the skin and the latter involving multiple organs.[1] Mast cell tumors are often seen in dogs and cats.[5]

Mast cell - Wikipedia, the free encyclopedia

[Kritters]

I love it, Jo.

More puzzle pieces found to help put this together.

You know, it brought to mind the word mastectomy (removal of breasts) yet when I googled it the word 'mast' wasn't really explained or defined. Maybe mastectomy is really removal of the mast cells and they fudged the definition.

xoxo
Kritts

[Jo]

Mast cells seem quite important and might become part of the jigsaw Kritts.

But they seem good and bad???

"Recent data suggests that mast cells may play an active role in such diverse diseases as atherosclerosis, malignancy, asthma, pulmonary fibrosis and arthritis. Mast cells directly interact with bacteria and appear to play a vital role in host defense against pathogens. "

The human mast cell: functions in physiology and d...[Front Biosci. 2001] - PubMed Result

Dr Klapow, who named the nematode Cryptostrongylus, thought that possibly CFS could be caused by mast cell instability.

CND: On Cryptostrongylus pulmoni and multisystemic illness

I think he's suggesting that some roundworms can secrete chemicals (VIP) that cause the mast cell instability - enabling the parasites to have a better chance of survival.

Clever, naughty, little toads

Jo xxx

[Kritters]

okay, Jo....
Sorry to COMPLETELY FORGET ABOUT YOUR THREAD HERE! What a freaking brain fogged moron I am! I started a thread and didn't even realize that just a few days earlier you did one also AND I RESPONDED TO IT. Now, I'm really scared about my mind. Not kidding.

Okay, how can we combine these two posts? I'll see if I can't revise mine, delete them and somehow accomplish that.

Sorry, bud! ;-(

Kritts

[Kritters]

Kritts Reposted this from TCM's post:

Word Ideas about Mast

--------------------------------------------------------------------------------

This may be more than most want to know about the origin of this word as it relates to mast cells and mastectomy. I did not copy the entire page, but there is more about other words and the relationship to the mast root word. Evidently mast has some connection to the Greek Mastos meaning breast meaning fatty food, meaning mast cells are fatty, too, containing lipids. Tomos is greek to cut as in meaning to resect:

Mast Mastectomy Mastitis Mastoid Mastodont Masturbate - Word Roots Medical Etymology

MAST id+ | NIPPLE or BREAST LIKE thus
^u also FAT FATTY or FOOD |
id+ | STEM TREE POLE SPAR and other
ERECT or STANDING items that
MASTER ATTENTION |
med> MAST CELL or FOOD CELL or
MASTOCYTE see below
MAST leads to MASTER see below
ply> | MAMMALS MUST SUCK FATTY FOOD |
note we group MAST with MAST~
~ MAST~ prefix for id+ | BREAST NIPPLE LIKE |
nyth> AMAZONS WERE AMAZING BECAUSE
TO BETTER HANDLE THE BOW
THEY MAY HAVE CHOSEN TO UNDERGO A
MASTECTOMY = BREAST RESECTION
gr MASTOS BREAST
TOMOS TO CUT as in RESECT
AMASTOS NO BREAST
med> AMASTIA NO BREAST
MASTECTOMY BREAST RESECTION
GYNECOMASTIA FEMALE LIKE BREAST
biol> MAST relates to FAT or LARD
BREAST MILK IS RICH IN FAT
MAST CELLS are LIPID RICH
ols eng MAEST FOOD ACORNS
ukr MAZLO LARD OIL
gr MASTAX MOUTH
sp MORDER BITE sug> MORSEL
MASTICAR TO CHEW perhaps from
SUCKING A BREAST or NIPPLE
lat MANDUCATUS MASTICATE
note MANDIBLE as if to SNIP SPLIT
ukr MORDA SNOUT
note see> MASTURBATION
~ MASTECTOMY or MAMMECTOMY
from MAST and ECTOMY = BREAST and REMOVAL
sug> AMAZON from A for LACKING and
MAZOS = BREAST

[Kritters]

Reposting here from other thread:

Thanks TC,

I'm inclined to think they didn't name the removal of a breast 'mastectomy' because of the fatty tissue. With so many names they could have used, I think that would be a vulgar and insensitive name when they have no problem using the word 'breast' when it involves the actual breast cancer, surgery, augmentation, etc.

No, I think there is something transparently hidden here. After posting last night, I spent a few hours googling and mast cells are implicated in tons of diseases.

Here's what I just read over again this morning from my Parasite Rex book:

"Immunologists have worked out how IgE (Immunoglobulin E) helps trigger these reactions (sneezing, coughing, etc.) When certain harmless substances get into the body-ragweed pollen, cat dander, or cotton fibers for example, B cells make IgE antibodies tailored to their shape. These antibodies then are anchored TO SPECIAL IMMUNE CELLS CALLED MAST CELLS THAT ARE FOUND IN THE SKIN, LUNGS AND GUT.Later, the harmless substance for which the IgE is made enters the body again. If it latches onto a single IgE antibody on a mast cell, nothing happens. But if it should latch onto two of them sitting side by side on the mast cell, the harmless substance switches it into action.

(IT GETS BETTER) (I wish I knew how to change font on this forum)

".....since allergies serve no good purpose, immunologists could only look on IgE as one of the rare shortcomings of the immune system. But then they discovered that IgE can be good for something: FIGHTING PARASITIC ANIMALS...."........"If animals are robbed of their IgE, they're overrun by parasites...."

Anyway... there are connections everywhere and, although I'm not a scientist, I am a researcher getting an education.

Kritts

[Kritters]

from TCM:

Okay, here we go Kritts, food fight LOL

mast cell or mastocyte as defined on cancerweb:

Definition: mastocyte from Online Medical Dictionary

(German Mast food + cyte) a mast cell.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 200

As defined on the link from my first post on this thread:

MASTOCYTE med> or MAST CELL implies FOOD CELL
THESE CELLS ARE COMMON
IN THE INTESTINE and ADIPOSE or EXOCRINE GLANDS

From the free dictionary:

Mast cells - definition of Mast cells by the Free Online Dictionary, Thesaurus and Encyclopedia.

Noun 1. mastocyte - a large connective tissue cell that contains histamine and heparin and serotonin which are released in allergic reactions or in response to injury or inflammation
labrocyte, mast cell
connective tissue - tissue of mesodermal origin consisting of e.g. collagen fibroblasts and fatty cells; supports organs and fills spaces between them and forms tendons and ligaments
somatic cell, vegetative cell - any of the cells of a plant or animal except the reproductive cells; a cell that does not participate in the production of gametes; "somatic cells are produced from preexisting cells";

mast cell
n.
A cell found in connective tissue that contains numerous basophilic granules and releases substances such as heparin and histamine in response to injury or inflammation of bodily tissues.

Connective tissue contains mast cells and some of this has fatty cells. So meet in the middle? LOL.

Anyway, I think personally that some allergies can kill you. Maybe they might be able to do this because of the lipid coatings found on many viruses. For instance my doctor told me there is some connection between allergy and whatever is going on with Morgellons. He feels there is a connection to viral infections, at least in my own case. When I feel particularly not well (with whatever detoxification is happening with the medications and herbs I take or the die off the parasites) then I am supposed to take a benadryl at night to minimize the reactions. So now this information has me rethinking the old adage about allergies never killing you. Maybe they do as perhaps they have something to do with aiding viruses to hide in the fat coating at least some produce. This could allow them to hide from the body's immune system.

In looking into this issue I found a web page which may help us to disable some of our viral infections using some low cost natural substances, one of which is coconut oil which lyses the lipid coating of lipid coated viruses. Definition lyses: Biochemistry, The dissolution or destruction of cells, such as blood cells or bacteria, as by the action of a specific lysin that disrupts the cell membrane, definition.

Natural Treatments for Genital Herpes, Cold Sores and Shingles

I will be looking into that supplement which is supposed to be as good as viral medications. I have never been a big fan of drugs and am always looking for a way out of using them. Especially if no doctor is required. LOL.

Life Extension article on using Cimetidine (Tagamet) to control Herpes and Shingles infections:

Le Magazine, March 2001 - Report: Tagemet To Treat Herpes And Shingles

Think Kritts wants to link this thread to the thread Jo started on mast cells, so am putting the link here to that thread:

Mast cell disruption?

Kritters, I am going to also try to find a thread about viral infection and post the above information about treating viral infections naturally there--I think it is very good information for those who have limited access to conventional medical care. Do you want me to delete the other information I added on this thread about the origin of the word for the mast cell?

[Kritters]

Hey TC...
I was away from my computer until now. I tried to compile everything into Jo's thread but had to stop. I'll put your info into a post for you as I try to blend them

Well, no food fight here, girlfriend.Esp. fatty lol... Why? Because that definition of Mastocyte is the connection I was looking for and strengthens my thinking on this, thanks. I didn't see that 'mastocyte' connection in any of the definitions I found. You must have some pretty good sources. The fact that a mastocyte is what fights parasites is enough for me so far. this means to me that they know parasites are involved in breast cancer and ask any doctor that question and he/she will probably deny it since there is that adamant stand that parasites aren't involved in breast or ANY cancer. the plot thickens.

Now I'm going to go back to Jo's original thread posts and re-read them.

With regard to mast cells so far and Morgellons, I'm wondering if our symptoms are actually mastocytes over-acting for some reason.

People die from allergies all the time. Fungus is usualy involved in food allergies. I'm going to read up on that again, and in my 'Rex' book there is a section I just got to and didn't get a chance to read. I'll get back to ya.

xo
Kritts

[Kritters]

Jo,

I wonder if most of the auto-immune diseases, which practically all have similar symptoms and actually inter-related diseases such as MS, CFS etc have been initially diagnosed at around the same time period. If so, why would the roundworm only affect the IgE of people at that time? Was it the time the parasite (Ascarias? Toxoplasma?) (According to Carl Zimmer (Parasite Rex author) just about everyone has Toxoplasma in their systems due to domestication of dogs and cats) found the key to fending off the mastocytes? And what about the people who don't have any of the autoimmune diseases but do have dogs or cats or have the parasite?

Could the herpes connection make the difference?

I know I sound like the announcer at the end of a soapbox episode. tune in tomorrow to watch.... as the stomach turns.

I know I'm mumbling thoughts and wandering seemingly aimlessly here, but also looking for my friend's thoughts ;-)

The other question I have is that if we do all have those parasites, our symptoms are from either the IgE going bananas because of the parasite's newfound weapons against it or the parasite itself taking over? I say it's door number one because of the symptoms.

I also wonder where the fibers come in. Are they just the fungus joining in the fun?

What's happening with Steve's theory? How's it coming along and what implications could there be, if any, to this?

Wow, it's just so weird how your thread seemed to slip away from my mind and then these questions came to me. There must be something significant about that. But I'll tell ya, this connection between mastocytes and mastectomy was another powerful eureka. Maybe this was why I was so depressed... the calm before the storm LOL.

Interesting.... if you google ANY of the autoimmune diseases, you'll see that they don't know what causes it, there is no cure, HOWEVER, there are medical treatments available. What does that tell us?

xoxo
Kritts

[Kritters]

"Under Cryptostrongylus Pulmoni- A new kind of nematode

3) It secretes powerful chemicals which may disrupt and inhibit the hosts TH2 antiparasitic immune response - Mast cells are destablized (2), meaning?? we can become a host for other parasitic infections, eg viral, fungal, bacterial..etc"


Jo,
What Dr. Klapow said about the cryptostrongylus makes so much sense. this does bring us back to that critter, doesn't it?

I looked up the lesion aspect of the diseases caused by excess mast cells and didn't see any that looked like mine or any others' I've seen on the forum. But the itching could be there anyway if they try to do their jobs against cryptostrongylus, hey?

geez, now I have to go back and read your threads on the crypto.

You're amazing, Joey!

Kritts