GM Pest Conrol Bacteria Jump to Humans

[carla]

From insects to man: identification of virulence factors involved in the adaptation of the emerging pathogen Photorhabdus asymbiotica to human hosts
Objectives: In view of their growing use in biological control, which increases the human potential rate of exposure to these pathogens, we undertook a comparative study between insect and human pathogenic strains of Photorhabdus, in an attempt to understand the genetic mechanisms involved in their recently acquired capacity to infect humans.
Results: Only P. asymbiotica human pathogenic isolates ATCC43949 and SN were able to adhere to human fibronectin and/or vitronectin, and to infect/invade HaCaT cells. This was inhibited in the presence of antibodies against human Fn or Vn. Only strain ATCC43949 induced cytotoxic effects after 6h co-culture with human cells. Cytoskeleton involvement in the P. asymbiotica infective process was indicated by blockage of infection and invasion by genistein, and by immunofluorescence analysis of infected cells.
Conclusion: The acquisition of virulence factors enabling P. asymbiotica to interact with human ECM and to human cells is a key factor in its evolution towards the colonisation of human hosts. ECM proteins are involved in the primary events during P. asymbiotica colonisation of human epithelial tissues, and the host cytoskeleton is solicited during the P. asymbiotica-epithelial cells interaction. Possible mechanisms used by P. asymbiotica to colonise human tissues are discussed.

European Society of Clinical Microbiology and Infectious Diseases

[Sadsack]

Here we go again, huh Carla? I wonder if this is in the toxic soup that infects our skin, along with agrobacteria?

Sometimes I think that we are somehow the "chosen" recepticles for Man's perversion of nature, that somehow all this genetic engineering and manipulation is being expressed in us...the canaries in the mineshaft.

SS

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CDC - Photorhabdus Species: Bioluminescent Bacteria Emerging as Human Pathogens?