HSLV-1 (herpes) & Strongyloides

[Morgan]

HSLV-1 has ABSOLUTELY NOTHING TO DO WITH HERPES. DON'T POST WHILE HALF ASLEEP.
IT IS IMPOSSIBLE TO CHANGE THE TITLE OF THIS THREAD SO PLEASE ACCEPT MY APOLOGIES.

I am very tired while typing this so please bear with me.

I was reading about Strongyloides and I came across a virus which makes it all but impossible to fight off a Strongyloide Stercoralis infection. That viruse is HSLV-1 or Human T-cell Lymphotropropic virus type-1 or Adult t-cell lymphoma virus type-1. This is becoming a more common virus infecting the population. If someone has a dormant Strongyloide infection for say two decades and somehow acquires this HSLV-1 virus then say gets some sort of corticosteroid therapy would this be the perfect storm for a parasitic infection/infestation which would be resistant to anti-helmentics?


Here is the infomration from the PubMed website concerning this phenomenon.

Epidemiological and clinical interaction between H...[Parasite Immunol. 2004 Nov-Dec] - PubMed Result

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Epidemiological and clinical interaction between HTLV-1 and Strongyloides stercoralis.Carvalho EM, Da Fonseca Porto A.
Federal University of Bahia, Hospital Universitário Prof. Edgard Santos, Serviço de Imunologia, Salvador-BA, Brazil. edgar@ufba.br

Strongyloides stercoralis is the most common human parasitic nematode that is able to complete a life cycle and proliferate within its host. The majority of patients with strongyloidiasis have an asymptomatic infection or mild disease. However, when autoinfection occurs, a high number of infecting larvae can gain access to the bloodstream by penetrating the colonic mucosa leading to a severe hyperinfection and the development of disseminated strongyloidiasis. The human T cell lymphotropic virus type 1 (HTLV-1) predominantly infects T cells and induces spontaneous lymphocyte proliferation and secretion of high levels of type 1 cytokines. Strongyloides stercoralis patients with HTLV-1 co-infection have a modified immunological responses against parasite antigens and co-infection has clinical implications for strongyloidiasis. The high production of IFN-gamma observed in patients co-infected with HTLV-1 and Strongyloides stercoralis decreases the production of IL-4, IL-5, IL-13 and IgE, molecules that participate in the host defence mechanism against helminths. Moreover, there is a decrease in the efficacy of treatment of Strongyloides stercoralis in patients co-infected with HTLV-1. Alterations in the immune response against Strongyloides stercoralis and the decrease in the efficacy of anti-parasitic drugs are responsible for the increased prevalence of Strongyloides stercoralis among HTLV-1 infected subjects and make HTLV-1 infection the most important risk factor for disseminated strongyloidiasis.

PMID: 15771684 [PubMed - indexed for MEDLINE]
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Morgan