Lactoferrin...any one used it?

[Janice]

I have been doing some research on this, and was currious if any one has used it. I am going to talk to my doc about this next week.
Sounds very interesting to me. Looking for people who may have used it. This is just a short ditty on Lactoferrin, there is alot of info on the subject.

LACTOFERRIN

Lactoferrin plays several biological roles related to its iron binding ability immune support and antioxidant activities. Lactoferrin prevents the growth of pathogens, has anti bacterial, anti fungal, and anti viral activity, controls cell tissue damage caused by oxidation and also facilitates iron transportation. Bacterial, viral and fungal infections are dependent on a supply of free iron for reproduction and survival. Lactoferrin binds the free iron and reduces the amount of oxidative free radicals released during the inflammation process.

Lactoferrin promotes intestinal health by scavenging iron and balancing healthy flora in the G.I. tract. By modulating healthy levels of iron in the body, Lactoferrin plays a key role in maintaining overall health. Some in vitro studies suggest that lactoferrin acts synergistically with antifungal agents.

Description

Lactoferrin is a glycoprotein that belongs to the iron transporter or transferrin family. It was originally isolated from bovine milk, where it is found as a minor protein component of whey proteins (see Whey Proteins). Lactoferrin contains 703 amino acids and has a molecular weight of 80 kilodaltons. In addition to its presence in milk, it is also found in exocrine secretions of mammals and is released from neutrophil granules during inflammation.

Lactoferrin is considered a multifunctional or multi-tasking protein. It appears to play several biological roles. Owing to its iron-binding properties, lactoferrin is thought to play a role in iron uptake by the intestinal mucosa of the suckling neonate. That is, it appears to be the source of iron for breast-fed infants. It also appears to have antibacterial, antiviral, antifungal, anti-inflammatory, antioxidant and immunomodulatory activities.

Three isoforms of lactoferrin have been isolated: lactoferrin-alpha, lactoferrin-beta and lactoferrin-gamma. Lactoferrin-beta and lactoferrin-gamma have RNase activity, whereas lactoferrin-alpha does not. Receptors for lactoferrin are found in monocytes, lymphocytes, neutrophils, intestinal tissue and on certain bacteria. Lactoferrin is abbreviated LF and Lf. Bovine lactoferrin is abbreviated bLF.

Bovine lactoferrin, derived from whey proteins, is marketed as a nutritional supplement. Supplemental lactoferrin typically contains low amounts of iron.


How it works

The possible antibacterial activity of supplemental lactoferrin might be accounted for, in part, by its ability to strongly bind iron. Iron is essential to support the growth of pathogenic bacteria. Lactoferrin may also inhibit the attachment of bacteria to the intestinal wall. A breakdown product of lactoferrin is the peptide lactoferricin. Lactoferricin, classified as a bioactive peptide, may also have antibacterial, as well as antiviral, activity. The possible antiviral activity of supplemental lactoferrin may be due to its inhibition of virus-cell fusion and viral entry into cells.

A few mechanisms are proposed for lactoferrin's possible immunomodulatory activity. Lactoferrin may promote the growth and differentiation of T lymphocytes. Lactoferrin appears to bind uniquely in the region of major histocompatability (MHC) proteins and the CD4 and CD8 determinants on T4 (helper) and T8 (suppressor) lymphocytes; it bears sequence homologies with the MHC Class II determinant. Lactoferrin also appears to play a role in the regulation of cytokines and lymphokines, such as tumor necrosis (TNF)-alpha and interleukin (IL)-6. Lactoferrin's possible antioxidant activity may also contribute to its possible immunomodulatory activity.

Lactoferrin's possible antioxidant activity can also be accounted for by its ability to strongly bind iron. Free iron is a major contributor to the generation of reactive oxygen species via the Fenton reaction.

Lactoferrin's possible anti-inflammatory action may be accounted for by its possible antioxidant and immunomodulatory activities.



Little is known of the pharmacokinetics of oral lactoferrin. Lactoferrin appears much more resistant to proteolytic action than most dietary proteins. Lactoferrin is digested in the intestine to the bioactive peptide lactoferricin. Most of the possible actions of oral lactoferrin may be confined to the gut. There is some preliminary evidence that lactoferrin and lactoferricin may be absorbed, in part, from the lumen of the small intestine into enterocytes and that these molecules enter other cells as well. However, this is unclear.
Benefits In Summary

A number of in vitro and animal studies have shown that lactoferrin has various bactericidal and fungicidal effects. It has exhibited significant activity against Escherichia coli, Proteus mirabilis, Staphyloccocus aureus, Candida albicans and other pathogens in these studies. In vitro, lactoferrin has similarly shown some significant activity against HIV, herpes simplex virus type 1, hepatitis C virus, cytomegalovirus and some other viruses.



Pregnant women and nursing mothers should avoid using lactoferrin supplements.

[Baraka Obam]

I have two bottles of it here, it seems I never really go started on it. I am takeing nothing else right now so I guess it would be ok to try it and see what happens.

I actually bought them for a trial but had some issues come up with blood pressure and stopped taking everything.

I just took my first one. It is a good time to see what happens.

[Janice]

Hi babe!
Cool. You have some. I know it sounds very interesting doesnt it. Keep me up to date on how your feeling. Janice

[xiblanque]

This was posted by one of our members D. Zig a while back. It didn't seem to generate too much interest at the time. I agree with Janice, a little research on the web yields a lot of great info concerning lactoferrin as a possible treatment for biofilm elimination.
Xib

"What I read was that biofilms can not be formed when enough Lactoferrin is present in the body. I read that sometimes the Lactoferrin of the body can not fight as it is supposed to....but....if you add a supplemental of Bovine Lactoferrin....it will begin to and continue to destroy bacteria and biofilm and parasitic conditions of the body. The best way I know how to put this is that the immune system has become stressed so much that the body's own Lactoferrin can't fight like it needs to....but with assistance of supplemental Lactoferrin....this can change....and Lactoferrin will kill off the 'bad stuff'.

So I picked up the bottle of Zymox.....cleaned off the tip....squirted some on a q-tip and put it in my nose. I doused my nasal passages with it...stuck the q-tip up and down as far as it would go and as far back as it would reach. Then I sniffed some of the Zymox liquid into my nose. The good thing about this is that it is sort of oily and IT STUCK WHERE IT NEEDED TO BE.

There is still so much to learn and I don't have a lot of time. But now that 'this door' has opened, I think it would be good to know how the LYSOZYME works in conjunction with LACTOFERRIN....and the LACTOPEROXIDASE.

QUESTION IS: Since all three are important to our IMMUNE SYSTEM, would it be better to supplement all three, rather than just one...One being the LACTOFERRIN?

LACTOPEROXIDASE can cause some unfriendly things. But, my question now is.....Would it be 'more friendly', if there was a supplemental balance of all three of the above?

We may find that the THREE OF THEM together as it is supposed to be could be EXTREMELY BENEFICIAL. I AM PERPLEXED.

HMMMMMMMM
D. Zig"



The "Zymox-Three Point Enzyme System OTIC Enzymatic Solution" comes WITH or WITHOUT
Hydrocortisone. I went straight for the stuff WITHOUT hydrocortisone, because I'm putting it in my mouth. Here's what's in it whether WITH or WITHOUT hydrocortisone.

INGREDIENTS: ZYMOX OTIC THREE POINT ENZYMATIC SOLUTION " Aids in the treatment of acute and chronic otitis externa due to bacterial and yeast infections"

GLYCERIN, DEIONIZED WATER, HYDROXY PROPYL CELLULOSE, BENZYL ALCOHOL, POTASSIUM IODIDE, DEXTROSE, PROPYLENE GLYCOL, GLUCOSE OXIDASE, LYSOZYME, LACTOPEROXIDASE, LACTOFERRIN.
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ZYMOX ENZYMATIC SHAMPOO: 12 Fluid Ounces

INGREDIENTS: WATER, DECYL GLUCOSIDE, LAURYL GLUCOSIDE, COCAMIDOPROPYL BETAIN, VITAMIN A VITAMIN B5, VITAMIN E, LYSOZYME, LACTOFERRIN, LACTOPEROXIDASE, ZINC GLUCONATE, POTASSIUM IODIDE, AND NATURAL FRAGRANCE.

IT SAYS ON THE BOTTLE: This effective shampoo was developed for pets experiencing minor bacterial and fungal skin infections. The first line of defense against infectious microbes is the skin. ZYMOX Shampoo uses the most gentle, non-drying cleaning agents available. We us only the mildest plant surfactants with protein based enzymes. ZYMOX Shampoo contains three enzymes to attack skin-irritating microbes.

EACH ENZYME HAS SHOWN TO BE INDEPENDENTLY POTENT AND WHEN COMBINED, PACKS A POWERFUL PUNCH. THIS NATURAL DEFENSE SYSTEM IS FOUND AND PRODUCED IN MILK SO IS SAFE AND GENTLE ON YOUR PET.

INSTRUCTIONS: APPLY SHAMPOO DIRECTLY (from bottle) OR DILUTED AT A RATIO OF 3 OUNCES TO ONE GALLON OF WATER. WASH ENTIRE ANIMAL CONCENTRATING ON PROBLEM AREAS. LEAVE LATHER ON FOR 3 TO 5 MINUTES THEN RINSE. REPEAT IF NEEDED. FOLLOW WITH ZYMOX RINSE FOR EXTRA ANTIMICROBIAL PROTECTION.

FOR EXTERNAL USE ONLY-AVOID CONTACT WITH EYES.
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"Well, guess I missed the boat on the RINSE...LOL. I didn't get any of that.

If this product is not targeted at the kinds of ... may I say....EXOTIC PROBLEMS ....we are all having.... I would be very surprised.

Reading this has sort of clarified for me that the three enzymes are probably much more powerful together and I need to keep researching this. I need to know how to get the proper balance....if it matters....of the three ingredients. But I gotta tell you....I looked up LYSOZYME last night and it is very expensive. DANG!

- - - - - - - - - - -

I looked everywhere and even found ZYMOX website, but you have to be a Vet to by from the ZYMOX website....as far as I could tell. But no trouble ordering from Amazon.com

It just seems crazy to me that no company for people has jumped on this
D. Zig"

Once again it seems that veterinarians often are trained to deal with and not discount issues such as fungi, pathogens, viruses and even internal biofilms that dermatologists and other specialists are quick to overlook.
Xib

[Janice]

Hi big boy! Just wondering if you feel ok taking the Lactoferrin. Any head aches , tummy problems, ect ? I want to start it. Janice

[jonsi]

Please everyone, be careful!

I used to experiment with supplements ( Dietary Supplement Fact Sheet: Selenium to be specific) & I started getting the worst back aches. My body didn't need this supplement, my body couldn't process it and the result was the "M" attacked it and made me sicker.

itwl,
~jonsi

[Janice]

I have an appointment with my doctor and we will talk about this. I have all my blood work taken every 3 months, and I am very careful, as I have other issues as well as morgellons. I think it is rather odd that a person who doesn't believe in getting lab test, and doesn't want to know specificaly what is wrong with them... tells other people to be careful.

[Janice]

Definition of LACTOFERRIN
: a red iron-binding protein synthesized by neutrophils and glandular epithelial cells, found in many human secretions (as tears and milk), and retarding bacterial and fungal growth


Not Selenium!

[Baraka Obam]

I have noticed that my kidneys are a littly affected and it seems that the pounding in my head has returned a slight amount, this means noting for if this is a strong fighter of this there will be some reaction to dieoff.

Zinc will also do this same thing to me.

[jonsi]

I was citing selenium as an example... many people take things that they don't need and they get sicker in the long run. Maybe you are right in that I should have taken a blood sample to see if I was deficient in selenium.

Traditional medicine did not work for me. I saw four MD's. They labeled me as DOP. I do not have health insurance.

Anyways, lab tests and pharmaceuticals are not "curing" most of us "M" sufferers.

I found natural/homeopathic medicine works for me & my daughter. Currently, I do not take any supplements except for a root extract for lymes that my homeopathic doctor prescribed for me.

I am sorry if I offended you. But I am not sorry if you find me "odd"! I am all that

Janice, thank you for the info. Please let us know how your appointment goes with your MD.

In the white light,
~jonsi