[kmar]

I find these two below interesting from one of the links provided above.

Notice the involvement of NIH and Department of Agriculture.

Thank for point these links out tcmgpt13.



Mechanisms and Functions of Human Sulfotransferases

The major goals of this project are to elucidate human sulfotransferase (SULT) chemical and kinetic mechanisms, to understand physiologic functions of SULTs, and to investigate their relevance to human health in physiologic and pathologic conditions. Research focus on: 1) mechanisms of enzyme catalysis, substrate inhibition, and product activation of human SULTs; 2) effect of clinical, widely used drugs on human sulfotransferase catalytic activities; and 3) oxidative regulation mechanisms of human SULTs.
Sponsor: National Institute of Health
PI: Guangping Chen
Division of Agricultural Sciences and Natural Resources: Richard Essenberg
University of Oklahoma: Paul Cook

Bioactive Food Components and Human Sulfotransferases
Many bioactive food components and active components in drugs are phenolics. These phenolics are substrates for human sulfotransferases (SULTs). They also inhibit SULTs (substrate-inhibition). Our recent data suggests that these compounds also induce human SULTs. This research project focuses on the relationships between bioactive food components and human SULTs, including how they are metabolized by SULTs, how they inhibit SULTs, and how they regulate human SULT genes.
Sponsor: United States Department of Agriculture